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FLASH GENE
Symbol TRBC1 contributors: - updated : 27-01-2004
HGNC name T cell receptor beta constant 1
HGNC id 12156
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 0.00 kb     4 Exon(s)
MAPPING cloned Y linked N status confirmed
Map see TRB@ and TRBJ@
Physical map
TRBVB 7q34 T cell receptor beta variable B TRBV27 7q34 T cell receptor beta variable 27 TRBV28 7q34 T cell receptor beta variable 28 TRBV29-1 7q34 T cell receptor beta variable 29-1 PRSS1 7q35 protease, serine, 1 (trypsin 1) TRY5 7q34 trypsinogen B TRY6 7q34 trypsinogen C TRY7 7q34 trypsinogen D PRSS2 7q35 protease, serine, 2 (trypsin 2) TRBD1 7q34 T cell receptor beta diversity 1 TRBJ1-1 7q34 T cell receptor beta joining 1-1 TRBJ1-2 7q34 T cell receptor beta joining 1-2 TRBJ1-3 7q34 T cell receptor beta joining 1-3 TRBJ1-4 7q34 T cell receptor beta joining 1-4 TRBJ1-5 7q34 T cell receptor beta joining 1-5 TRBJ1-6 7q34 T cell receptor beta joining 1-6
regionally located located downstream the TRBV@ and the the first TRBJ@ and upstream TRBD2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text thymocyte
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal extracellular segment, folded into one constant, Ig-like domain
  • a transmembrane segment (TM1)
  • a short cytoplasmic tail
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION anchoring the T cell receptor to the plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular immunity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding the cognate constant alpha chain by a disulfide bond
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS