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FLASH GENE
Symbol MSMB contributors: mct/npt/pgu - updated : 15-02-2018
HGNC name microseminoprotein, beta-
HGNC id 7372
DNA
TYPE functioning gene
STRUCTURE 13.04 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure promoter region containing a conserved steroid-hormone responsive element and an estrogen-responsive element in the first intron, suggesting possible regulation of this gene by sex hormones
MAPPING cloned Y linked   status confirmed
Physical map
LOC387672 10 similar to Ribosome biogenesis protein BMS1 homolog LOC387673 10 similar to Glutamate dehydrogenase, mitochondrial precursor (GDH) LOC338598 10q11.22 similar to hypothetical protein MGC5560 LOC118706 10q11.22 similar to ARF GTPase-activating protein LOC387674 10 similar to Ribosome biogenesis protein BMS1 homolog MGC35285 10q11.22 hypothetical protein MGC35285 MAPK8 10q11.2 mitogen-activated protein kinase 8 RhoGAP2 LOC387675 10 LOC387675 LOC159491 LOC389964 10 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein KIAA1607 FLJ31737 LOC170370 10q11.23 hypothetical LOC170370 LOC170371 10q11.23 hypothetical protein LOC170371 LOC118461 DRG11 ERCC6 10q11 excision repair cross-complementing rodent repair deficiency, complementation group 6 PGBD3 10q11 piggyBac transposable element derived 3 CHAT 10q11.2 choline acetyltransferase SLC18A3 10q11.2 solute carrier family 18 (vesicular acetylcholine), member 3 LOC282966 10q11.23 hypothetical protein LOC282966 FLJ10851 10q11.23 hypothetical protein FLJ10851 MAPK6PS6 10q11.21 hypothetical protein FLJ10851 PARG 10q11.23 poly (ADP-ribose) glycohydrolase LOC387676 10 similar to KIAA0592 protein LOC387677 10 hypothetical gene supported by BC051717; NM_133446 LOC255319 10q11.23 similar to ARF GTPase-activating protein MSMB 10q11.2 microseminoprotein, beta- NCOA4 10q11.2 nuclear receptor coactivator 4 TIMM23 10q11.21-q11.23 translocase of inner mitochondrial membrane 23 homolog (yeast) LOC387678 10 similar to ARF GTPase-activating protein LOC389965 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC387679 10 similar to KIAA0592 protein LOC387680 10 similar to KIAA0592 protein LOC389966 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) ASAH2 10q11.21 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 LOC387681 10 hypothetical gene supported by BT007130; NM_001378 MOB 10q11.2 mob protein LOC340858 10q21.1 similar to hypothetical protein FLJ10539 FLJ31958 10q21.1 hypothetical protein FLJ31958 LOC389967 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389968 10 similar to Cathepsin L preproprotein LOC283023 10q21.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) ACF 10q21,1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) PRKG1 10q11.2 protein kinase, cGMP-dependent, type I CSTF2T 10q22-q23 protein kinase, cGMP-dependent, type I
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 572 12.9 114 - 1991 2054385
variant PSP94
3 - 466 8.7 77 - 1991 2054385
variant PSP57
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemovary    Homo sapiens
 male systemprostate    Homo sapiens
 male systemseminal vesicles   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion seminal fluid
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • beta-microseminoprotein family
  • immunoglobulin superfamily
  • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus
    basic FUNCTION
  • may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues
  • playing a role in hormonal control at the pituitary gonadal axis
  • functions as a suppressor of tumor growth and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component seminal plasma protein, forming a tight complex with cysteine-rich secretory protein 3 (CRISP3) from granulocytes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EZH2 (MSMB is silenced by EZH2 in advanced prostate cancer cells)
  • interact with cysteine-rich secretory protein 3 (CRISP3) in seminal plasma
  • both MSMB and an adjacent gene, NCOA4, are subjected to transcriptional control via androgen response elements
  • MSMB bind human CRISP3 (cysteine-rich secretory protein 3) with very high affinity
  • MSMB is a key upstream factor in mediating PRSS8 signaling that regulates PRSS8 expression and action in ovarian cancer cells
  • CRISP2 is a potential binding protein of MSMB
  • CRISP3 binds specifically and with high affinity to MSMB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    suppression of MSMB expression promotes anchorage-independent growth of prostate epithelial cells, but not growth of breast epithelial cells
    tumoral     --low  
    in ovarian cancer with reduced survival
    Susceptibility
  • to prostate cancer, HPC13 (OMIM 611928)
  • to spermatogenic failure associated with male infertility
  • Variant & Polymorphism SNP
  • increasing the risk of prostate cancer
  • rs10993994 is the strongest associated variant to risk of prostate cancer
  • rs10993994 associated with risk of spermatogenic failure
  • Candidate gene
    Marker
  • prostate cancer (PC) biomarker
  • Therapy target
    ANIMAL & CELL MODELS