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FLASH GENE
Symbol ORM1 contributors: npt/ - updated : 18/12/2008
HGNC name orosomucoid 1
HGNC id 8498
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 3.46 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 847 - 201 - -
  • a 18 aa signal peptide of 2 kda
  • a 183 aa mature peptideof 21.6 kda
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   specific
    Reproductivemale systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion abundantly in plasma
    at STAGE
    physiological period perinatal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES other
    STRUCTURE
    motifs/domains
    secondary structure a single eight-stranded continuously hydrogen-bounded antiparallel beta-barrel which encloses an internal ligand binding site
    conjugated GlycoP , Other
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Orm1 (52.6 pc)
    homolog to murine Orm1 (50.3 pc)
    Homologene
    FAMILY
  • calycin superfamily
  • lipocalin family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a crucial role in maintaining homeostasis
  • modulating the activity of the immune system during the acute-phase reaction
  • may be involved in aspects of immunosuppression
  • affecting pharmacokinetical properties of various therapeutic agents
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by glucocorticoids, interleukin-1 and interleukin-6 (increased 5- to 50-fold upon inflammation)
    Other pyrrolidone carboxylic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS