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FLASH GENE
Symbol MDH2 contributors: mct - updated : 03-03-2017
HGNC name malate dehydrogenase 2, NAD (mitochondrial)
HGNC id 6971
DNA
TYPE functioning gene
STRUCTURE 19.49 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2268 - 338 - 2015 25766404
8 - 2142 - 296 - 2015 25766404
8 - 2099 - 231 - 2015 25766404
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivestomach   highly
Lymphoid/Immunetonsils   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Mor1
Homologene
FAMILY
  • LDH family
  • MDH subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the eight step of citric acid cycle
  • acetylation of MDH2 was affected by the cellular energy state and subsequently regulated adipogenic differentiation
  • mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle
  • plays an essential role in the malate-aspartate NADH shuttle, which is the main pathway whereby reducing equivalents from cytosolic NADH are transferred to mitochondria
  • involved in citric acid cycle in mitochondria
  • MDH2 stimulated by estrogen, was involved in the development of PTEN-regulated endometrial carcinoma through GPER1-related pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE51
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in endometrial carcinoma tissues and related to the grade of the cancer
    tumoral germinal mutation      
    in malignant paragangliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    a novel MDH2 inhibitor, compound 7, suppressed HIF1A accumulation via reduction of oxygen consumption and ATP production, integrating metabolism into anti-cancer efficacy in cancer cells
    ANIMAL & CELL MODELS