SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus
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text
| located on the cytosolic face of the plasma membrane |
basic FUNCTION
| calcium dependent phospholipid binding protein, modulating antiinflammatory response (phospholipase A2 inhibitory activity) |
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involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system |
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role of endogenous ANXA1 in the protective and reparative properties of the intestinal mucosal epithelium |
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mediating the glucocorticoid inhibition of cyclic adenosine 3', 5'-monophosphate-stimulated prolactin secretion |
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promoting membrane fusion |
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mediator of the anti-inflammatory actions of endogenous and exogenous glucocorticoids (GC) |
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regulating the MAPK/ERK pathway |
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potent inhibitor of hormone exocytosis in the neuroendocrine system, acting in a paracrine/juxtacrine manner |
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fundamental for brain homeostasis |
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Ca(2+)-dependent membrane binding protein, which has been implicated in membrane trafficking and reorganization |
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important component of phagocytosis that appears to link actin accumulation to different steps of phagosome formation |
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multifunctional, calcium-dependent phospholipid binding protein involved in a host of processes including inflammation, regulation of neuroendocrine signaling, apoptosis, and membrane trafficking |
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may be required for the constitutive activity of IKBKB and NFKB in highly metatstatic breast cancer |
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required for the recruitment of RIPK1 to the IKK complex, which may be important for the activation of NFKB |
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critical for the constitutive activation of NFkB in breast cancer to promote metastasis |
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expressed in brain microvascular endothelial cells, where it regulates blood–brain barrier(BBB) integrity |
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is a stabilizer for fibrillar actin and consequently cell polarity |
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ANXA1 complex coordinates the actions of PRKCA and PRKCB to control the distribution of oxytocin vesicles between the axon and the cell body |
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ANXA1 expression is "tumor-specific" and might play a multifaceted role in cancer development and progression |
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contributes to the pathological consequence and sequelae of most serious human diseases including cardiovascular disease and cancer |
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role for ANXA1 in shaping the adaptive immunity against M. tuberculosis |
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endogenous annexin A1 (ANXA1) is released as a component of extracellular vesicles (EVs) derived from intestinal epithelial cells, and these ANXA1-containing EVs activate wound repair circuits |
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is essential in cell differentiation and proliferation |
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potential role of ANXA1 in the regulation of bone marrow-derived mesenchymal stem cell (BM-MSC) proliferation and osteogenic differentiation |
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is a key modulator of mesenchymal stromal cell-mediated improvements in islet function |
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nuclear translocation of ANXA1 is involved in neuronal apoptosis after ischemic stroke |
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plays a pivotal role in APP clearance |
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promotes the proliferation of esophageal squamous cell carcinoma (ESCC) cells, and increases the expression of SNAI1, whereas it inhibits that of CDH1, thus enhancing the migration and invasion of ESCC cells |
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is a glucocorticoid-regulated protein known for its anti-inflammatory and pro-resolving effects |
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is at least one of the endogenous determinants mediating the pro-resolving properties of cAMP-elevating agents and cAMP-mimetic drugs |