motifs/domains
| two C4HC3 zinc finger protein motifs |
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two nuclear bipartite localization signals (NLS1,NLS2) |
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a putative histone acetyltransferase, (MYST domain) |
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an acidic proline-glutamine and a methionine-rich domain (SM domain) |
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a HAT domain containing a central region that is structurally and functionally conserved with the yeast, and harboring a DNA-binding activity |
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a nuclear localization domain (including H15), |
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a double-plant homeodomain finger that binds to acetylated histone H3 tails (PHD 1 and 2) |
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an acidic glutamate/aspartate-rich region, and a serine and methionine-rich region that comprises a transactivation domain |
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large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain |
basic FUNCTION
| involved in chromatin remodeling and general gene expression |
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involved in regulating transcriptional activation mediated by RUNX2 |
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essential transcriptional coactivator and histone acetyltransferase (HAT) that plays a primary role in the differentiation of erythroid and myeloid cells and is required to maintain hematopoietic stem cells |
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DNA-binding activity of MYST3 may be at the heart of the oncogenic effect in AML-associated chromosomal translocations |
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acting as a transcriptional coactivator for AML1, which is essential for establishment of definitive hematopoiesis |
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involved in regulating cell-cycle arrest in the G1 phase |
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essential for the generation and maintenance of hematopoietic stem cells (HSC) and for the appropriate development of myeloid, erythroid and B-lineage cell progenitors |
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regulates H3K9 acetylation at Hox gene loci and retinoic acid can act independently of MYST3 to establish specific Hox gene expression boundaries |
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critical requirement in hematopoietic stem cell development and maintenance |
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specifically required for the H3K9 acetylation of transcriptionally active Hox gene loci |
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KAT6A/KAT6B are histone acetyltransferase (HATs) important for different developmental programs and have been implicated in leukemogenic and other tumorigenic processess |
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tandem PHD fingers of KAT6A/KAT6B acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin |
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has important roles in gene-specific histone acetylation, regulating developmental gene expression and in TP53 acetylation and signaling |
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critical function in haematopoiesis |
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induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification |
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role of wild-type KAT6A in regulating B-cell progenitor proliferation and hematopoietic malignancy. |
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required to maintain the proliferative capacity of B-cell progenitors, even in the presence of MYC overexpression, by directly maintaining the transcriptional activity of genes required for normal B-cell development |
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through histone and non-histone acetylation, KAT6A affects multiple cellular processes and illustrates the complex role of acetylation in regulating development and disease |
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is a potent inhibitor of senescence via the CDKN2A pathway |
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KAT6A and BMI1, respectively, promoted and repressed HOX genes during the shift from the transcriptionally repressed to the active state |