protein
| SKP2 with a core ubiquitin ligase (SCF) |
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CDK2/cyclin A (CCNA) |
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FBXL16 |
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interacts with CENPE at the midbody and participates in cytokinesis (CENPE degradation is essential for faithful mitotic exit and the proteolysis of CENPE is mediated by SCF (SCF complex Skp1/Cul1/F-box protein/Roc1) via a direct SKP1 link |
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interaction with Elongin C (are structural elements responsible for selective interaction with their cognate Cullin/Rbx1 modules) |
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cochlear FBXO2 binds SKP1, the common binding partner for F-box proteins, and is an unusually abundant inner ear protein |
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SKP1 binding prevented FBXO7 from contacting XPO1 |
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competitive binding mechanism between SKP1 and exportin 1 (XPO1) controls the localization of a subset of F-box proteins |
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can directly interact with FBXO7, a gene defective in PARK15-linked Parkinson disease |
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DRG2 was a substrate of a SKP1-CUL1-F-box E3 ligase complex and inhibition the function of Cullin1 prevented the degradation of DRG2 during apoptosis |
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regulates BRCA1 protein stability |
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SF3B3 overexpression reduces the binding of adaptor protein SKP1 and substrate receptor SKP2 to CUL1, whereas it has no effect on CAND1 binding to CUL1 |
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SUGT1 interacts with SKP1, a small protein that heterodimerizes with proteins containing the F-box motif |
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role for SKP1 as an auxiliary component of the target recognition module that enhances binding of FBXO45 to NMNAT2 |