Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRKDC contributors: mct/npt - updated : 04-01-2013
HGNC name protein kinase, DNA-activated, catalytic polypeptide
HGNC id 9413
DNA
TYPE functioning gene
STRUCTURE 187.07 kb     86 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
86 - 13509 - 4128 - Danoy (2008)
85 - 13416 - 4097 - Danoy (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Digestiveliver    
 mouthgingiva  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
Homologene
FAMILY
  • PRK family
  • PIK, phosphatidylinositol kinase family
  • PI3/PI4-kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DNA dependent serine/threonine protein kinase catalytic subunit, phosphatidylinositol kinase
  • involved in DNA double-strand break repair by end joining (non homologous recombination NHEJ) and V(D)J recombination
  • central regulator of DNA double-strand break (DSB) repair
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with Ku antigen (see KUP70 (G22P1) and KUP80 (XRCC5) at DNA double strand break ends, recruiting XRCC4-ligase, facilitated by POLM
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • KIP2
  • WRN (inhibition of both the helicase and exonuclease activities of WRN)
  • interaction between PRKCD and PRKDC participates in apoptosis induced by DNA damage
  • interacting with HNRNPU (phosphorylation of HNRNPU by PRKDC suggests novel functions for PRKDC in the response to DNA damage)
  • CENPF is associated with the DNA-dependent protein kinase (PRKDC), a trimeric protein complex critical for genome homeostasis
  • NR4A1, NR4A2 interact with PRKDC and, upon exposure to DNA damage, translocate to DSB foci by a mechanism requiring the activity of PARP1
  • DEAF1 can interact with the PRKDC complex through interactions of its DNA binding domain with the C-terminal region of XRCC6 that contains the BAX binding domain, and is a potential substrate for PRKDC
  • NR5A1 restricts centrosome overduplication by inhibiting aberrant activation of DNA-dependent protein kinase (PRKDC) in the centrosome
  • has fundamental roles in Classical nonhomologous end joining (C-NHEJ) processes beyond end processing that have been masked by functional overlaps with NHEJ1
  • novel regulatory pathway where signaling from PRKDC appears to suppress midbrain-specific LMX1A expression
  • DNA-damage-induced Golgi dispersal requires GOLPH3/MYO18A/F-actin and the DNA damage protein kinase, PRKDC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD26
    Susceptibility to radiosensitivity in a patient with xeroderma pigmentosum
    Variant & Polymorphism other splice variant associated with radiosensitivity in a patient with xeroderma pigmentosum (Abbaszadeh 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS