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FLASH GENE
Symbol CLC contributors: mct - updated : 14-12-2005
HGNC name Charcot-Leyden crystal protein
HGNC id 2014
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticbasophil
Blood/Hematopoieticeosinophil
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one galectin domain
HOMOLOGY
Homologene
FAMILY galactin family of beta-glactoside binding -type lectins
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,granule
basic FUNCTION
  • eosinophil lysophospholipase, hydrolyzing lysophosphatidylcholine to glycerophosphocholine and a free fatty acid
  • may be associated with inflammation and some myeloid leukemias
  • may have both lysophospholipase and carbohydrate-binding activities
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    phospholipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ige binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS