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FLASH GENE
Symbol CALD1 contributors: mct - updated : 21-08-2014
HGNC name caldesmon 1
HGNC id 1441
DNA
TYPE functioning gene
STRUCTURE 191.32 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ40288 7q32.3 hypothetical protein FLJ40288 FLJ20420 FAM10A7 11p15-p14 family with sequence similarity 10, member A7 SEC8 FLJ32786 7q33 hypothetical protein FLJ32786 SLC35B4 7q33 solute carrier family 35, member B4 AKR1B1 7q25 aldo-keto reductase family 1, member B1 (aldose reductase) AKR1B10 7q33 aldo-keto reductase family 1, member B10 (aldose reductase) LOC392097 7 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BPGM 7q32 2,3-bisphosphoglycerate mutase LOC392098 7 similar to beta-tubulin CALD1 7q33-q34 caldesmon 1 LOC340351 7q33 hypothetical protein LOC340351 LOC346671 7q33 pseudogene of RING finger protein 14 FLJ11000 7q33 hypothetical protein FLJ11000 MGC5242 7q33 hypothetical protein MGC5242 KIAA1466 7q33 KIAA1466 protein HSPC049 7q33 HSPC049 protein LOC346673 7q33 STRA8 LOC346674 7q33 similar to Na+/L-ascorbic acid transporter 1; SVCT1 CNOT4 7q33 CCR4-NOT transcription complex, subunit 4 LOC392099 7 hypothetical gene supported by AK075360; NM_003002 NUP205 7q33 nucleoporin 205kDa LOC136321 7q33 similar to 60S ribosomal protein L15 SLC13A4 7q33 solute carrier family 13 (sodium/sulfate symporters), member 4 LOC389558 7 similar to HWKM1940 MTPN 7q33-q35 myotrophin LOC392100 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5241 93.26 793 predominantly expressed not only in smooth-muscle cells but also in pericryptal fibroblasts in colon 2011 21626272
  • h-CAD, or V1, h-Caldesmon
  • variable in 3'utr length
  • 14 - 4476 62.56 538 non muscle, widely expressed and localized in podosomes/invadopodia 2011 21626272
  • l-CAD1, or V2, l-Caldesmon
  • lacking exon 4
  • lacking the central domain
  • reduction in l-caldesmon facilitates podosome/invadopodia formation and metastasis in colon carcinoma
  • 13 splicing 4291 - 558 cell line 2011 21626272
  • l-CAD2, or V4
  • insertion exon 4
  • 15 - 4551 - 564 - 2011 21626272
    12 - 4213 - 532 - 2011 21626272
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node     Mus musculus
     spleen   highly Mus musculus
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • F-actin cross linking protein
  • acts as a potent repressor of cancer cell invasion
  • one of the key regulators for actin dynamics and thereby cell polarity, membrane extension, and cell motility
  • playing a role in the regulation of endothelial cytoskeleton and migration
  • actin- and myosin-binding protein found in smooth muscle that inhibits actin activation of myosin ATPase activity
  • actin-linked regulatory protein found in smooth muscle and non-muscle cells
  • important regulator of axon development
  • CALD1, regulated by SOX4 transcriptional activity, contributes to skeletal muscle differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • biological cascade that involved the phosphorylation activation of CALD1 by CDK14 in promoting formation of actin stress fibers
  • SOX4 is a major trans-acting factor for the regulation of CALD1 expression during myoblast differentiation
  • KAT5 chromodomain was found to facilitate SOX4 recruitment to the CALD1 promoter, which is involved in chromatin remodeling at the promoter
  • cell & other
    REGULATION
    Other its function is regulated qualitatively by Ca2+/CALM1 and by its phosphorylation state and quantitatively at the mRNA level, by three different transcriptional regulation of the CALD1 gene
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS