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FLASH GENE
Symbol MCM7 contributors: mct/npt/pgu - updated : 16-01-2018
HGNC name minichromosome maintenance complex component 7
HGNC id 6950
DNA
TYPE functioning gene
STRUCTURE 11.98 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2821 81 719 - 1998 9714754
14 - 2900 - 543 - 1998 9714754
14 - 3105 - 543 - 1998 9714754
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MCM domain found in DNA-dependent ATPases required for the initiation of eukaryotic DNA replication
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm7 (minichromosome maintenance mutant)
    homolog to murine Mcmd7
    homolog to Drosophila Mcm7
    homolog to C.elegans Mcm7
    intraspecies homolog to cell division cycle 47 (CDC47)
    Homologene
    FAMILY
  • MCM family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • in G1 of the two-cell stage, both nuclei had salt-resistant ORC2 and MCM7
  • basic FUNCTION
  • participating in the cell cycle control of genome duplication
  • acting as a factor allowing the DNA to undergo a single round of replication per cell cycle
  • required for DNA replication and cell proliferation
  • required for S-phase checkpoint activation upon
  • UV-induced damage
  • plays a direct role in the transmission of DNA damage signals from active replication forks to the S-phase checkpoint machinery in cells
  • DNA replication protein that is essential for initiation of DNA replication and maintenance of genomic integrity
  • involved in prostate cancer progression, growth and invasion
  • independent prognostic factor for human colorectal cancer
  • having an essential role for DNA replication
  • during S phase, functions as part of the replicative helicase but within the pre-replication complex MCM7 is inactive
  • having a role in establishment of bidirectional replication forks
  • during S phase MCM7 functions as part of the replicative helicase but within the pre-replication, MCM7 is inactive
  • is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell entry into S phase
  • is an essential component of DNA replication licensing complex
  • MCM7 is likely a critical RNA splicing factor
  • plays a critical role in the initiation of gene replication
  • as a result of MCM7 overexpression, CEP68 was targeted for ubiquitination and proteasomal degradation, thereby rendering centrosome splitting
  • LMNB2 interaction with MCM7 promotes non-small cell lung cancer (NSCLC) progression
  • CELLULAR PROCESS cell cycle
    nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
  • signaling cascade in which EGFR enhances MCM7 phosphorylation and DNA replication through LYN phosphorylation in human cancer cells
  • a component
  • CDC45/MCM2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase
  • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • histone H3
  • MCM8
  • interacts with the ATR-ATRIP complex, and with RAD17
  • interacting with CDKN1B
  • is a novel RAD17-interacting protein
  • interaction with EIF3E (proteasome inhibition strengthens interaction between both proteins and EIF3E stabilizes MCM7)
  • interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression
  • CCNA2 and MCM7 interact in the chromatin fraction (interaction with Mcm7 is essential for the function of cyclin A in promoting S-phase entry)
  • MCM7 interacts with the receptor for activated protein kinase C 1 (RACK1), a protein kinase C (PKC) adaptor
  • NCOA4 is a minichromosome maintenance 7 (MCM7)-interacting protein that is able to control DNA replication
  • MCM7 binds SF3B3, and the binding motif is located in the N terminus (amino acids 221-248) of MCM7
  • directly complexes with CEP68 and VHL
  • LMNB2 binds to the C-terminus of MCM7, and competes with the binding of the tumor suppressor retinoblastoma (RB1) protein
  • cell & other
    REGULATION
    activated by MYCN
    induced by growth factor stimulation at the late G1 to S phase
    Phosphorylated by by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive prostate cancer
    tumoral     --other  
    deregulation might be involved in medulloblastoma tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for molecular targeted cancer therapy in various tumors
  • Marker
  • MCM7 polymorphisms may be able to predict the prognosis of acute myeloid leukemia (AML) patients
  • good prognostic biomarker for non-small cell lung cancer patients
  • Therapy target
    ANIMAL & CELL MODELS