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FLASH GENE

Symbol

HSD17B3

contributors: npt/ - updated : 30-09-2005

HGNC name	hydroxysteroid (17-beta) dehydrogenase 3
HGNC id	5212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	66.85 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map

see NBCCS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 11 - 1134 isoform 1 34.4 310 - Persson (2009)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately Nervous brain       moderately Reproductive male system testis     predominantly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Hsd17b3
	ortholog to rattus Hsd17b3

Homologene

FAMILY	short-chain dehydrogenases/reductases (SDR) family
	17-beta-HSD 3 subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	playing an essential role in the formation of active intracellular sex steroids
	catalyzing the conversion of androstenedione to testosterone (last step of testosterone biosynthesis)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	sex determination

PATHWAY

metabolism

lipid/lipoprotein , hormone

signaling

steroid biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	NADPH

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HSD17B3D

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS