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FLASH GENE
Symbol RPA3 contributors: mct/pgu - updated : 05-03-2012
HGNC name replication protein A3, 14kDa
HGNC id 10291
DNA
TYPE functioning gene
STRUCTURE 81.66 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1613 13.4 121 - 2009 19010961
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
 brain    
 braindiencephalonhypothalamus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to yeast Rfa3
ortholog to Schizosaccharomyces pombe Ssb3
Homologene
FAMILY replication protein A family
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • playing a role in DNA replication, repair, and recombination
  • with RPA1, and RPA2, plays essential roles in DNA transactions
  • single-stranded (ss) DNA-binding protein highly conserved in eukaryotes and playing essential roles in many aspects of nucleic acid metabolism, including replication, recombination, DNA repair and telomere maintenance
  • playing potentially a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair, nucleotide excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a trimeric single strand binding protein,the replication protein A complex,involved in replication,homologous recombination and nucleotide excision repair
  • INTERACTION
    DNA interacting directly with ssDNA
    RNA
    small molecule
    protein
  • interacts with the specific proteins among those that play roles in the regulation of the replication fork progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS