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FLASH GENE
Symbol SERPINI1 contributors: mct/npt/shn - updated : 09-02-2013
HGNC name serpin peptidase inhibitor, clade I (neuroserpin), member 1
HGNC id 8943
DNA
TYPE functioning gene
STRUCTURE 89.93 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D3S1264 - D3S1253 - SERPINI1 - D3S3622 - D3S1614 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 1696 55 410 - -
9 splicing 1929 55 410 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • high molecular weight, reactive center loop characteristic of serpins
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Serpini1, Mus musculus
    ortholog to Serpini1, Rattus norvegicus
    ortholog to serpini1, Danio rerio
    ortholog to SERPINI1, Pan troglodytes
    Homologene
    FAMILY
  • serpin family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text localised to dense cored secretory vesicles in PC12 cells
    basic FUNCTION
  • implicated in the regulation of proteases involved in processes such as synaptic plasticity, neuronal migration and axogenesis
  • may play an important role in regulating axonal growth
  • a role in axon and dendritic growth
  • a key role as a regulator of neuronal development through a non-inhibitory mechanism
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS nervous system
    text putative regulator of extracellular proteolysis at growth cones or synapses
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • single-chain plasminogen activator, sct-PA and two-chain plasminogen activator, tct-PA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FENIB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS