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FLASH GENE
Symbol ART3 contributors: mct/npt - updated : 25-08-2008
HGNC name ADP-ribosyltransferase 3
HGNC id 725
DNA
TYPE functioning gene
STRUCTURE 38.00 kb     12 Exon(s)    1 Copie(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • presence of two alternative promoters termed palpha and pbeta (in heart, skeletal muscle and tonsils the upstream promoter palpha was totally inactive and ART3 transcription appears to be driven solely by pbeta)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1559 41.5 367 - Levy, Okada (2008)
    - splicing 1598 43.9 389 - Strausberg, Okada (2008)
    - - 1565 - 378 - Okada (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunethymus    
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • two disulfide bonds
  • a hydrophobic peptide signal at its N terminus
  • three consensus motifs specific to enzymes catalyzing ADP-ribose transfer
  • a hydrophobic C-terminal sequence characteristic of a GPI-anchored protein with a novel motif repeated 3 times and a potential
  • glycosylation site
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans R08A2.2
    Homologene
    FAMILY
  • mono (ADP-ribosyl) transferase family
  • Arg-specific ADP-ribosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text GPI anchored membrane protein
    basic FUNCTION
  • transfering an ADP-ribose moiety from NAD+ to a specific amino acid in the target protein
  • exerts a specific function only required at a particular stage of spermatogenesis
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NAD
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-obstructive azoospermia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS