basic FUNCTION
| activator of gene expression in hepatocytes (such as albumin and transthyretin), respiratory and intestinal epithelia |
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regulates a complex pulmonary program of epithelial cell maturation required for transition to air breathing at birth |
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important in regulation of prothrombin expression |
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represses transcription of OATP8 |
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regulates 5-aminolevulinate synthase gene expression and is involved in insulin repression |
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may be a novel tumor suppressor gene in lung cancer |
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regulating with nuclear factor 1 the 5-aminolevulinate synthase gene (ALAS1) expression and involved in insulin repression |
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required for cell-specific activation of the glucagon gene in pancreatic islet alpha-cell |
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playing a role in opening the chromatin at the start site of transcription of the glucagon gene |
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playing an important role in MUC2 mucin expression in the intestine during goblet cell differentiation |
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important regulator of MUC2 expression in the intestine |
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regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner |
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cooperate with FOXA1 during liver and lung morphogenesis |
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LMX1A and LMX1B cooperate with FOXA2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon |
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in melanoma cells, FOXA2 expression is silenced and therefore PI3 is maintained unexpressed to facilitate cell proliferation in the disease melanoma |
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important regulator of glucose and lipid metabolism and organismal energy balance |
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FOXA2, H2AFZ mediate nucleosome depletion during embryonic stem cell differentiation |
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H2AFZ and FOXA2 both act to regulate nucleosome depletion and gene activation, thus promoting ES cell differentiation, whereas DNA methylation promotes nucleosome occupation and suppresses gene expression |
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FOXA1, FOXA2 are required for activation of SHH in the notochord |
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activates lipid metabolism and ketogenesis during fasting and is inhibited via insulin-PI3K-AKT1 signaling-mediated phosphorylation at Thr156 and nuclear exclusion |
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a later role for FOXA1, FOXA2 genes in regulating the maintenance of dopaminergic phenotype in mesodiencephalic dopaminergic (mDA) neurons |
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is a master regulator of endoderm development and pancreatic beta cell gene expression |
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plays a pivotal role in regulating intestinal epithelial cell function |
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promotes cell proliferation, maintains cancer stem cells, favors the development of Triple-Negative/Basal-like tumors, and is associated with increase relapses |
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plays an important in development, cellular metabolism and tumorigenesis |
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plays a crucial role in islet development and endocrine functions |
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plays essential roles in liver development and bile acid homeostasis |
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FOXA2, a Transcription factor controlling pancreas specification, broadly contributed to the cis-regulatory networks of Pancreatic ductal adenocarcinoma (PDAC) |