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FLASH GENE

Symbol

EYA2

contributors: mct - updated : 21-01-2015

HGNC name	eyes absent homolog 2 (Drosophila)
HGNC id	3520

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	294.23 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005244 16 - 2702 NP_005235 59.2 538 - 2002 12039049 EYA2 I, V1 EYA2 II ,V2 - - 2762 - 543 - 2002 12039049 EYA2 III ,V3 - - 2508 - 538 - 2002 12039049 EYA2 IV ,V4 - - 2458 - 538 - 2002 12039049 NM_172110 14 - 2483 NP_742108 - 459 - 2002 12039049 EYA2 V5

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Nervous brain         Urinary kidney         Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular

cell lineage
cell lines	neuroblastoma cell lines
fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	placenta,brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C terminal large highly conserved domain,the EYA homology domain,
	a basic segment followed by an alpha helical domain composed of four successive repeats forming a leucine zipper

HOMOLOGY

Homologene

FAMILY

phosphatase subgroup of the haloacid dehalogenase-like (HAD)hydrolase superfamily

CATEGORY

unknown/unspecified , receptor membrane tyrosine phosphatase

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION	may be involved in eye development
	participating directly in the modulation of cellular signaling through its phosphatase activity
	prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/AKT1/MTOR signaling pathway
	is a necessary co-factor for many of the metastasis promoting functions of SIX1, suggesting that targeting the SIX1-EYA interaction may inhibit breast cancer progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	transcriptional and translational component
	EYA2-SIX1 complex binds to and enhances the expression of MTOR in a synergistic manner

INTERACTION

DNA

RNA

small molecule

protein	SIX1 is dependent on EYA2 to mediate numerous pro-metastatic characteristics
	EYA2 in a physical complex with SIX1 plays a critical role in physiological hypertrophy of heart
	FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
	CDK6 binds to and promotes degradation of the EYA2 protein (interaction suggesting that CDK6 regulates EYA2 activity, a mechanism that could be important in development and in cancer)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   was significantly associated with short overall survival in advanced ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary potential application as a therapeutic target in ovarian cancer

ANIMAL & CELL MODELS