basic FUNCTION
| tyrosine phosphatase, non receptor, that may be involved in protein amino acid dephosphorylation |
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play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors |
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matrix-controlled PTPN2 phosphatase activity can inhibit VEGFR2 signalling, and the growth, migration and differentiation of human endothelial cells |
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playing a functional role in maintaining the intestinal epithelial barrier and in the pathophysiology of Crohn disease |
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regulates cytokine-induced apoptosis and may thereby contribute to the pathogenesis of type 1 diabetes |
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might protect beta-cells from virus-induced apoptosis |
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may contribute to the pathogenesis of diabetes by modifying the beta-cell responses to a viral infection |
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may thus modulate beta-cell apoptosis and/or local release of inflammatory mediators in the course of a viral infection by acting, at least in part, at the pancreatic beta-cell level |
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tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins |
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important functional role for PTPN2 as a protector of the intestinal epithelial barrier |
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play an important role in the protection of epithelial barrier function during periods of inflammation by acting as a negative regulator of the proinflammatory cytokine IFNG1 |
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attenuates T-cell lymphopenia-induced proliferation |
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in addition to modulating FGFR3 phosphorylation, PTPN1 and PTPN2 constrain the kinase domain by fostering an inactive-state |
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crucial role for PTPN2 in chronic intestinal inflammation |