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FLASH GENE
Symbol C6 contributors: - updated : 15-01-2007
HGNC name complement component 6
HGNC id 1339
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text tail to tail with C7
STRUCTURE 71.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   specific
 pancreas exocrine   highly
Respiratorylung   highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short consensus repeats (Sushi (CCP/SCR) domains)
  • a perforin domain
  • three thrombospondin type I (TSP type-1) domains (see F13B, SRCP1)
  • an EGF-like domain
  • a LDL-receptor class A domain
  • a MACPF domain
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine C6
    ortholog to rattus c6
    ortholog to chimpanzee c6
    Homologene
    FAMILY complement C6/C7/C8/C9 family
    CATEGORY immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • membrane attack complex
  • basic FUNCTION
  • stabilizing C5b
  • involved in the formation of the lytic c5b-9m complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with other late components of the cascade to form the membrane attack complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C5b
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C6
    related resource C6base - Mutation registry for C6 deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS