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FLASH GENE
Symbol HIVEP1 contributors: mct/npt/pgu - updated : 12-05-2013
HGNC name human immunodeficiency virus type I enhancer binding protein 1
HGNC id 4920
DNA
TYPE functioning gene
STRUCTURE 152.51 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D6S1446 - D6S1034 - D6S1279 - HIVEP1 - D6S961 - D6S1721 - D6S1077 - D6S1491 - D6S1593 - D6S443 - D6S1578 - D6S429 - D6S259 - CD83 - D6S289 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 8891 - 2718 - 2010 20226436
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
Lymphoid/ImmuneB cell
Lymphoid/Immunemacrophage
cell lineage
cell lines retinal cell lines, Hela cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sets of two zinc fingers being widely separated
  • a fifth zinc finger in-between (C2H2 type, Krüppel-like)
  • ZAS1 and ZAS2 motifs
  • eight T/SPRX/K motifs
  • HOMOLOGY
    interspecies ortholog to murine Hivep1
    homolog to Drosophila shn
    homolog to C.elegans R11A8.7B
    intraspecies paralog to HIVEP2,HIVEP3
    Homologene
    FAMILY
  • Schnurri protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text nucleolar protein
    basic FUNCTION
  • involved in transcriptional activation and repressing C-myc transcription
  • inducing mitochondrial involvement in the apoptotic process
  • participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions
  • directly participate in the transcriptional regulation of a variety of genes by binding to their promoter NF-KB consensus sequences
  • unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to enhancer MHC sequence
  • binding to a positive regulating domain of the IFN-beta promoter
  • binding to 5'-GGGACTTTCC-3' sequence which is found in the enhancer elements of numerous viral promoters such as those of SV40,CMV or HIV1
  • RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to MHC,positive regulatory domain II (HIV - EP1/MBP1/PRDII - BF1)
  • HIVEP1-CIRH1A interaction (CIRH1A up-regulates a canonical NF-kappaB element through strong interaction with HIVEP1)
  • TRAPPC2 interact with HIVEP1, a repressor of the MYC promoter (pMID: 24098805)
  • cell & other
    REGULATION
    induced by mitogen,serum,virus and phorbol ester
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to venous thrombosis
    Variant & Polymorphism other rs169713C allele associated with an increased risk for venous thrombosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS