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FLASH GENE
Symbol CCNB1 contributors: mct/npt/pgu - updated : 26-11-2013
HGNC name cyclin B1
HGNC id 1579
DNA
TYPE functioning gene
STRUCTURE 11.16 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • E2F1 binds to the CCNB1 promoter and maintains its expression and subsequent cell cycle progression in AR-negative stromal cells or AR-positive stromal cells when androgens are depleted.
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LOC206227 5q13.1 similar to B-cell lymphoma 9 protein (Bcl-9) (Legless homolog) LOC359819 5q12.3 mitochondrial ribosomal protein L39 pseudogene EEF1B3 5q12-q14 eukaryotic translation elongation factor 1 beta 3 PIK3R1 5q12-q13 phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) SLC30A5 5q12.1 solute carrier family 30 (zinc transporter), member 5 CCNB1 5q11-q12 cyclin B1 CENPH 5p15.2 centromere protein H MRPS36 5q13.3 mitochondrial ribosomal protein S36 CDK7 2p15-pcen cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) KENAE 5q13.1 Kenae LOC285653 5q13.1 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein TAF9 5q12 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa RAD17 5q12-q13.1 RAD17 homolog (S. pombe) FLJ30532 5q13.1 hypothetical protein FLJ30532 OCLN 5q13.1 occludin GTF2H2 5q13.1 general transcription factor IIH, polypeptide 2, 44kDa BIRC1 5q13.1 baculoviral IAP repeat-containing 1 SMN1 5q13.1 survival of motor neuron 1, telomeric LOC391791 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SMA3 5q13 SMA3 LOC389294 5 similar to bA110H4.2 (similar to membrane protein) LOC391792 5 similar to SMA3 protein LOC340089 5q13.2 similar to bA110H4.2 (similar to membrane protein) LOC391793 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SERF1A 5q13.1 small EDRK-rich factor 1A (telomeric) SMN2 5q13.1 survival of motor neuron 2, centromeric LOC389295 5 LOC389295 LOC389296 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC389297 5 similar to bA110H4.2 (similar to membrane protein)
    RNA
    TRANSCRIPTS type messenger
    text two alternative forms, one constitutive, the other cell cycle-regulated
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2101 48.2 433 - 1998 9582266
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     liver   moderately
     salivary gland   moderately
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone  moderately
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion predominantly in lymph
    at STAGE
    cell cycle     cell cycle, checkpoint, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic retention signal (CRS1)
  • a leucine-rich nuclear export signal (NES)
  • a N terminal cyclin domain
  • a C terminal cyclin domain
  • conjugated PhosphoP , Other
    HOMOLOGY
    interspecies homolog to rattus Ccnb1 (87 pc)
    homolog to murine Ccnb1 (86.7 pc)
    Homologene
    FAMILY
  • cyclin family
  • Cyclin AB subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text accumulating in the cytoplasm through S and G2 phases and translocating to the nucleus during prophase after phosphorylation by Polo-like kinase
    basic FUNCTION
  • regulating G2/M transition (checkpoint) of the cell cycle
  • nucleocytoplasmic shuttling protein
  • involved in positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
  • involved in proliferation, and aggressiveness of prolactin pituitary tumors
  • critical factor in proliferation and differentiation of endometrial cells, and progesterone may inhibit cell proliferation, mediate G2/M cell cycle arrest and induce apoptosis in endometrial cells via down-regulating CCNB1
  • CCNB1 and CCNB2 are particularly critical for the maintenance of the mitotic state
  • critical regulator of mitotic entry via its interaction with cyclin-dependent kinase 1
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CDC2 (M phase promoting factor (MPF) component), antagonized by PPP2CA
  • CDK1/CCNB1 activity shields cells against extrinsic death stimuli and unravel the molecular details of the crosstalk between cell cycle and extrinsic apoptotic pathways
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF)
  • binding to CCNB1IP1
  • CDK5 activation in cells that overexpress CCNG1 leads to MYC phosphorylation on Ser-62, which is responsible for CCNG1-mediated transcriptional activation of CCNB1
  • interacting with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase
  • overexpression of AURKA may stabilize CCNB1 through inhibiting its degradation
  • different levels of CCNB1-CDK1 kinase activity trigger different mitotic events, thus revealing how the remarkable reorganization of the cell is coordinated at mitotic entry
  • CCNA2 helps initiate mitosis, in part through its effects on CCNB1, and CCNB1 and CCNB2 are particularly critical for the maintenance of the mitotic state
  • CPEB1 is bound and represses cyclin B1 mRNA translation until a signal to proliferate phosphorylates CPEB1, resulting in an increase in cyclin B1 protein and progression into mitosis
  • TSC2 binds and regulates the G 2/M cyclin, cyclin B1
  • CDK1/CCNB1-dependent hyper-phosphorylation of BCL2L11 during prolonged mitotic arrest is an important cell death signal
  • SPARC induced G2/M cell cycle arrest was mediated through inhibition of the CCNB1-regulated signaling pathway involving CDKN1A and CDC2 expression
  • STOX1 promotes mitotic entry by binding to the CCNB1 promotor
  • CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
  • cell & other
    REGULATION
    repressed by AR (negative regulation of CCNB1 by AR is mediated through switching between E2F1 and E2F4 on the promoter of CCNB1
    Other phosphorylated by PLK and independently but perhaps synergically by MAPK (ERK2) at different sites in the CRS and translocated to the nucleus
    ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction
    its expression is regulated by cytoplasmic polyadenylation element binding protein in astrocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression of cyclins B could contribute to the chromosomal instability observed in cancer
    tumoral     --other  
    aberrantly expressed in non-small cell lung cancer and some precursor lesions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS