Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TARS | contributors: mct - updated : 18-05-2018 |
HGNC name | threonyl-tRNA synthetase |
HGNC id | 11572 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 27.40 kb 19 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence |
MAPPING | cloned | Y | linked | N | status | provisional |
Map | pter - D5S108 - D5S1993 - D5S1986 - D5S1996 - CDH6 - D5S477 - D5S1884 - D5S1470 - TARS - D5S651 - D5S2433 - D5S674 - TRIM28 - D5S2062 - D5S1430 - D5S1506 - D5S583 - D5S1867 - D5S1479 - D5S2077 - D5S493 - D5S663 - D5S631 - D5S426 - D5S1900 - D5S2573 - D5S1750 - D5S455 - SLC1A3 - NUP155 - MLVI2 - D5S1994 - D5S2025- D5S1859 - D5S1876 - D5S1998 - D5S395 - PRLR - LIFR - D5S1879 - D5S2592 - cen |
Authors | Peterson (99) |
RNA |
TRANSCRIPTS | type | messenger |
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|
EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
mono polymer | homomer , dimer |
HOMOLOGY |
Homologene |
FAMILY | class-II aminoacyl-tRNA synthetase family |
CATEGORY | enzyme , RNA associated |
SUBCELLULAR LOCALIZATION | extracellular |
intracellular | |
intracellular,cytoplasm,cytosolic | |
intracellular,cytoplasm,cytoskeleton |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
interacting with zinc ions |
protein |
cell & other |
REGULATION |
Other | regulated by feedback mechanisms |
borrelidin competes with all three aminoacylation substrates, providing a potent and redundant mechanism to inhibit TARS during protein synthesis |
ASSOCIATED DISORDERS |
corresponding disease(s) | TTD7 |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene | ||
Marker
Therapy target
|
| |
ANIMAL & CELL MODELS |