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FLASH GENE
Symbol ZNF3 contributors: - updated : 21-07-2003
HGNC name zinc finger protein 3 (A8-51)
HGNC id 13089
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 13.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1625 - 387 - Pannuti
- splicing 2603 - 410 - Pannutti
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid    
Nervousbrain    
Reproductivefemale systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage myeloid cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger protein with one KRAB (Kruppel-associated box) domain
  • five tandemly arranged zinc finger motifs of the C2H2 Kruppel-type
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to UCP1,UCP3,highly
    Homologene
    FAMILY
  • zinc finger protein family
  • mitochondrial anion carrier protein
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in transcriptional regulation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional repression
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other G/A polymorphism promotes decrease risk of obesity in middle-age
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS