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FLASH GENE
Symbol PGC contributors: - updated : 15-11-2006
HGNC name progastricsin (pepsinogen C)
HGNC id 8890
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Map see GLO1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 stomach   specific
Endocrinepancreas    
Nervousnervecranial nerve  moderately
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 16 aa signal peptide
    • isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to dog PGNB (62.8 pc)
    homolog to chimpanzee PGC (99 pc)
    homolog to rattus Pgc (74.7 pc)
    homolog to murine Pgc (74.8 pc)
    homolog to chicken CPGC (65.7 pc)
    Homologene
    FAMILY
  • peptidase A1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in proteolysis and peptidolysis
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS