basic FUNCTION
| involved in T cell antigen receptor mediated signaling |
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functioning as an adaptor or scaffold |
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regulating blood and vascular separation (through hematopoietic signaling pathway) |
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involved in controlling the separation of the lymphatic and blood vascular systems |
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required for TCR-induced tyrosine phosphorylation and activation of ITK but was not required for the phosphorylation or activation of ZAP70 |
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having dual role in mediating T cell receptor-induced activation of phospholipase C-gamma1 (PLCG1) |
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can exert a cross-regulatory or feedback control on the clustering of ZAP70, an element previously thought to operate exclusively upstream of LCP2 |
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regulates the other cytoplasmic kinase and adaptor ZAP-70 and GADS, whereas upstream transmembrane LAT operates independently in the TCR signaling cascade |
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through its protein-binding domains, serves as a platform for the assembly of multiple enzymes and adapter proteins that function together to activate second messengers required for TCR signal propagation |
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novel role in regulating HIV-1 infection in T cells with the potential to develop innovative strategies against HIV-1 |
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novel role in CXCR4-mediated T lymphocyte trafficking |
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is an essential signaling component for basophil activation downstream of both FCER1A and the IL3 receptor |