Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LCP2 contributors: mct/npt/pgu - updated : 07-06-2015
HGNC name lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
HGNC id 6529
DNA
TYPE functioning gene
STRUCTURE 49.73 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2472 - 533 - 2007 17420479
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Endocrinepancreas   moderately
Nervousbraindiencephalonhypothalamus  
Reproductivemale systemprostate  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage cells of hematopoietic origin (peripheral blood leukocytes)
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal acidic region with a PEST domain, and tyrosine residues, N-terminal phosphotyrosines, that play a critical role in T-cell adhesion under flow
  • sterile alpha motif
  • 67 AA functional domain within the proline-rich region (P1 domain)
  • a 10 AA-long sequence upstream the GADS binding site, a LCK binding region essential for T cell antigen receptor signaling and normal T cell development and function
  • one SH2 domain at the C terminus that binds to FYB, and MAP4K1
  • HOMOLOGY
    interspecies homolog to murine Lcp2
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in T cell antigen receptor mediated signaling
  • functioning as an adaptor or scaffold
  • regulating blood and vascular separation (through hematopoietic signaling pathway)
  • involved in controlling the separation of the lymphatic and blood vascular systems
  • required for TCR-induced tyrosine phosphorylation and activation of ITK but was not required for the phosphorylation or activation of ZAP70
  • having dual role in mediating T cell receptor-induced activation of phospholipase C-gamma1 (PLCG1)
  • can exert a cross-regulatory or feedback control on the clustering of ZAP70, an element previously thought to operate exclusively upstream of LCP2
  • regulates the other cytoplasmic kinase and adaptor ZAP-70 and GADS, whereas upstream transmembrane LAT operates independently in the TCR signaling cascade
  • through its protein-binding domains, serves as a platform for the assembly of multiple enzymes and adapter proteins that function together to activate second messengers required for TCR signal propagation
  • novel role in regulating HIV-1 infection in T cells with the potential to develop innovative strategies against HIV-1
  • novel role in CXCR4-mediated T lymphocyte trafficking
  • is an essential signaling component for basophil activation downstream of both FCER1A and the IL3 receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    LCP2/GRAP2/NCK1 adaptor protein pathway, implicated in regulation of the actin cytoskeleton by BCR-ABL kinase
  • critical for ITK-SYK activation and is particularly required for the ITK-SYK-dependent phosphorylation of SYK activation loop tyrosines
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding LAT (linker for activation of T cells by GRAP2 (GADS)
  • GRB2, FYB and PLCG1
  • SYK (interaction required to regulate separation of blood and lymphatic vascular networks)
  • binds to the src homology 3 domain of LCK
  • direct interaction between LCP2 and CD6 was shown by binding both to a phosphorylated peptide
  • interaction with FYB (role for the LCP2-FYB module in LFA1-mediated costimulation in T cells)
  • ongoing physical interaction between LCP2 and ITK is required to maintain ITK in an active conformation
  • ITK-LCP2 interaction in cytokine production
  • associates with PIK3R1 after T cell activation and LAT recruits this complex to the membrane, leading to AKT1 activation
  • interaction of FYB1 with LCP2 enables the formation of persistent microclusters and the stabilization of T cell contacts, promotes integrin-independent adhesion and enables the upregulation of CD69
  • FYB1 acts upstream of LCP2 to convert labile, Ca2+-competent microclusters into stable adhesive junctions with enhanced signaling potential
  • cell & other
    REGULATION
    Other phosphorylated by TCR coupled tyrosine kinase
    combined phosphorylation of separate tyrosine residues forms the basis of synergistic NK cell activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS