protein
| RAN binding protein, RAN GTPase RANGAP1 |
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CHC1 generating RAS-GTP, required for nuclear localization and chromatin-induced mitotic spindle formation |
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binding to AR (androgen receptor) |
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binding to the importin site of karyopherins beta (KPNBx) |
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interacting with NUP153 Ran-binding zinc finger domain |
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mediates these mitotic events, in part, by facilitating the correct targeting of the kinase Aurora A and the kinesins to spindles |
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import cargo of NUTF2 |
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increases AR transactivation by enhancing the AR interaction in the nucleus |
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RAN is a novel MAD2L2 binding protein (protein-protein interaction may play a role in the control over the spindle checkpoint during mitosis andin the regulation of nucleocytoplasmic trafficking during interphase (pMID: 19753112) |
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with RANBP2, anchor RAPGEF3 to the nuclear pore, permitting cAMP signals to activate RAP1A at the nuclear envelope) |
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interacts with the nuclear import protein importin-beta2 in a manner dependent on the CLS (ciliary localization signal) and inhibited by RAN |
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interacting with RCC1 (recruits RAN to nucleosomes and activates RAN nucleotide exchange activity) |
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interaction with XPO6 (reduction of its activity leads to actin accumulation via failure of RANGTP restoration and NUTF2 sequestration in the nuclei of senescent cells |
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connection between the hyper-activation of the small GTPase RAN and the matricellular protein SMOC2 that has important consequences for oncogenic transformation |
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MYC binds to the upstream sequence of RAN and transactivates RAN promoter activity |
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TACC3is also a target of the RAN GTPase system, and it may coordinate with RAN to regulate acentrosomal microtubules for kinetochore capture |
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BIRC5 is a potential RAN target gene (inhibition of BIRC5 reduced cell proliferation and induced apoptosis by down-regulating CCND1 and phospho-Rb and activating CASP3) |
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RAN is involved in the process of VHL nuclear-cytoplasmic trafficking following microtubule network alteration in hypoxic cardiomyocytes (CMs) |
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RAN-dependent TPX2 activation promotes acentrosomal MT nucleation in neurons |
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EMD and RAN are direct binding partners of TMEM201, but RAN attenuates the interaction between EMD and TMEM201 |
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VSMC proliferation can be modulated via an HSPD1 dependent, cytosol localized mechanism that in part involves a stimulation of nuclear protein import through an interaction with RAN |