basic FUNCTION
| may be functioning as a cell adhesion molecule, lacking probably the catalytic activity of tyrosine kinase |
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plays an important role not only in tube formation, migration, and invasion of endothelial cells but also in angiogenesis |
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planar cell polarity component expressed in the myeloid progenitor compartment that conveys promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor of survival in patients treated with induction chemotherapy |
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acting as a novel regulator of planar cell polarity |
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role for PTK7 in cell proliferation and cell apoptosis |
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functions upstream from glycogen synthase kinase 3 ( |
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role for PTK7 in the Wnt canonical signalling pathway ( |
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tyrosine kinase receptor implicated in planar cell polarity, a process with multiple implications at the cellular and organism levels |
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pseudokinase that can serves an essential role in FLT1-mediated angiogenesis |
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functions potentially in non-canonical Wnt signalling by turning off the canonical signalling branch |
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acts in conjunction with the noncanonical Wnt pathway to orient epithelial Planar cell polarity (PCP) through modulation of myosin II-based contractile tension between supporting cells and hair cells |
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function as a regulator of planar cell polarity during development |
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role for PTK7 in the tumorigenesis via generation of PTK7-CTF2 by sequential cleavage of ADAM17 and gamma-secretase |
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PTK7 inhibits actin cytoskeleton contractility, whereas by shedding the PTK7 ectodomain MMP14 activity reverses this inhibitory effect |
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regulates vertebrate planar cell polarity (PCP), controlling mesodermal and neural convergent-extension (CE) cell movements, neural crest migration and neural tube closure in vertebrate embryos |
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role for PTK7 protein as a modulator of LRP6 that negatively regulates Wnt/PCP activity |
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regulates epithelial morphogenesis and planar cell polarity (PCP) through modulation of actomyosin contractility |
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both PTK7 expression and proteolysis, rather than the level of the cellular full-length PTK7 alone, contribute to efficient directional cell motility and metastasis in cancer |