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FLASH GENE
Symbol PDCD2 contributors: mct - updated : 05-12-2023
HGNC name programmed cell death 2
HGNC id 8762
DNA
TYPE functioning gene
STRUCTURE 9.34 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site
text structure BCL6 binding sites,methylation free CpG island spanning their promoter region
MAPPING cloned Y linked   status provisional
regionally located closely linked to TBP
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3355 - 344 ubiquitously in various tissues including the brain 2020 33245768
  • variant 1 or PDCD2-1
  • containing the MYND zinc-finger domain
  • interacts with PARK2 that controls its degradation
  • 3 - 2682 - 228 - 2020 33245768
    7 - 3256 - 311 - 2020 33245768
    5 - 1107
    5 - 2583 - 195 - 2020 33245768
    4 - 1233 - 221 - 2020 33245768
    5 - 1134 - 188 - 2020 33245768
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    skin tegumentgerminal center cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one MYND finger domain
    HOMOLOGY
    interspecies homolog to rattus Rp8
    homolog to drosophila Zfrp8
    intraspecies paralog to PDCD2L
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • programmed cell death (apoptosis) and regulation of cell proliferation
  • PDCD2 plays a critical role in regulating the transcriptional hierarchy controlling hematopoietic lineage determination
  • effects of PDCD2 in regulating mitotic cell death may contribute to its role(s) in directing hematopoietic differentiation during development
  • PDCD2 functions likely at late stages of ribosome assembly and may regulate the binding of specific mRNA-RNPs to the small ribosomal subunit ultimately controlling their cytoplasmic localization and translation
  • PDCD2L and its paralog, PDCD2, function redundantly in 40S ribosomal subunit production
  • is essential for cell proliferation and embryonic development
  • functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL6 (target of BCL6 repression, repression by BCL6 is likely important in the pathogenesis of certain human lymphomas)
  • it is plausible that repression of PDCD2 expression by BCL6, which, in turn, leads to downregulation of apoptosis, is one mechanism involved in BCL6-associated lymphomatous transformation
  • PDCD2 interacts with RPS2 connecting ribosome maturation and gene-specific translation
  • PDCD2 specifically interacts with the 40S ribosomal protein uS5 (RPS2)
  • cell & other
    REGULATION
    repressed by BCL6 (role in lymphomagenesis)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute leukemia cells as well as in normal hematopoietic progenitors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    attractive, novel potential molecular target for new anti-cancer therapies
    ANIMAL & CELL MODELS
  • unique role for PDCD2 in regulating the cell cycle and p53 activation during early embryonic development of the mouse