basic FUNCTION
| programmed cell death (apoptosis) and regulation of cell proliferation |
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PDCD2 plays a critical role in regulating the transcriptional hierarchy controlling hematopoietic lineage determination |
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effects of PDCD2 in regulating mitotic cell death may contribute to its role(s) in directing hematopoietic differentiation during development |
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PDCD2 functions likely at late stages of ribosome assembly and may regulate the binding of specific mRNA-RNPs to the small ribosomal subunit ultimately controlling their cytoplasmic localization and translation |
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PDCD2L and its paralog, PDCD2, function redundantly in 40S ribosomal subunit production |
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is essential for cell proliferation and embryonic development |
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functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2) |