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FLASH GENE
Symbol MEP1A contributors: - updated : 27-10-2005
HGNC name meprin A, alpha (PABA peptide hydrolase)
HGNC id 7015
DNA
TYPE functioning gene
STRUCTURE 46.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see PKHD1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelial    
Membranemucouslamina propriaintestine villi 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide,
  • a propeptide,
  • a protease domain containing an astacin signature,
  • a meprin A-5 protein tyrosine phosphatase mu(MAM),
  • a meprin and TRAF homology (MATH)domain,
  • an after MATH (AM) domain,
  • an EGF like domain,
  • a putative transmembrane segment (1TM)
  • a short cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY astacin family of zinc metalloendopeptidases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted forms
    basic FUNCTION hydrolysing basement membrane components such as collagen IV, nidogen-1 and fibronectin
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associating with MEP1B
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS