Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC17A1 contributors: mct/ - updated : 19-01-2011
HGNC name solute carrier family 17 (sodium phosphate), member 1
HGNC id 10929
DNA
TYPE functioning gene
STRUCTURE 49.16 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • has a TATA-like box but no CAAT box, and the transcription start site was identified by primer extension and 5'-rapid amplification of cDNA ends
  • expression transcriptionally regulated
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1859 - 467 - 2003 14531806
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments (12TM) with cytosolic N and C termini
  • a motif in the fourth TM domain charcacteristic of the ACS family
  • HOMOLOGY
    intraspecies paralog to SLC17A2, SLC17A3, SLC17A4
    Homologene
    FAMILY
  • major facilitator superfamily
  • sodium/anion cotransporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • phosphate transport protein, Na+ dependent
  • cotransporters in the apical membrane of renal proximal tubular cells play a major role in the maintenance of P(i) homeostasis
  • urate transporter, which mediates the transmembrane cotransport of Na+/Pi in oocytes
  • Cl&
  • 8722;-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
  • polyspecific anion transporter with substrate specificity distinct from those of other SLC17 members
  • transports aspirin and salicylate, participating in the renal excretion of urate and nonsteroidal anti-inflammatory drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to gout
    Variant & Polymorphism other
  • polymorphisms are associated with the development of gout
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS