Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | LIFR | contributors: mct - updated : 18-09-2020 |
HGNC name | leukemia inhibitory factor receptor |
HGNC id | 6597 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 131.60 kb 20 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
text structure |
MAPPING | cloned | Y | linked | status | provisional |
Map | pter - OSMR - LIFRAS - LiFR - cen |
Authors | Hammarsund (2004) |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
mono polymer | heteromer , dimer |
HOMOLOGY |
interspecies | homolog to murine Lifr |
Homologene |
FAMILY | class I hematopoietin receptor family |
CATEGORY | receptor |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
text | type 1 transmembrane protein |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | inflammation |
PATHWAY |
metabolism |
signaling |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
inhibited by | SOCS3 (LIFR signaling is under tight negative regulation by the intracellular protein suppressor of cytokine signaling 3 (SOCS3)) |
ASSOCIATED DISORDERS |
corresponding disease(s) | SWS |
Susceptibility |
Variant & Polymorphism
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Candidate gene | candidate therapeutic strategy for demyelinating disease | |||||||||||||
Marker | ||||||||||||||
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Therapy target
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ANIMAL & CELL MODELS |