Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GHR | contributors: mct - updated : 03-07-2013 |
HGNC name | growth hormone receptor |
HGNC id | 4263 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 298.10 kb 10 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
MAPPING | cloned | Y | linked | N | status | confirmed |
Map | pter - D5S2023 - D5S1715 - GDNF - D5S2021 - D5S1964 - D5S205 - D5S1460 - D5S2642 - D5S2422 - D5S2113 - D5S648 - D5S502 - HMGCS1 - D5S2570 - C9 C9 - D5S627 - D5S419 - C7 - DAB2 - D5S2614 - D5S418 - D5S2581 - D5S1901 - D5S1497 - D5S1836 - D5S501 - D5S2022 - D5S1543 - D5S2438 - PTGER2 - RPL37 - D5S1457 - D5S2425 - C6 C6 - D5S634 - D5S420 - D5S430 -[ D5S2379 - D5S2082 - D5S2063 - D5S2087 - D5S1423 - D5S1857 ] - ZNF131 - D5S1485 - D5S175 - D5S2086 - cen |
Authors | Peterson (99) |
Text | [GHR ] |
RNA |
TRANSCRIPTS | type | messenger |
---|
text |
|
EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
tissue |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | pregnancy |
Text | placenta |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
|
HOMOLOGY |
interspecies | homolog to murine Ghr |
Homologene |
FAMILY | cytokine family of receptors |
CATEGORY | signaling hormone , receptor |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
intracellular | |
intracellular,cytoplasm,organelle,mitochondria | |
intracellular,nucleus | |
text | |
|
basic FUNCTION | |
| |
| |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | hormonal |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
| |
|
cell & other |
REGULATION |
Other | GHR endocytosis occurs independently of GH and requires BTRC that is recruited to the UbE motif in the cytoplasmic tail and a downstream degron, DSGRTS, binding to BTRC |
GHR expression is regulated by free fatty acids (FFA) |
ASSOCIATED DISORDERS |
corresponding disease(s) | GHIS1 , GHIS2 |
Susceptibility | to hypertension in female |
Variant & Polymorphism other | GHRd3 genotype increasing the risk of hypertension among stroke patients, particularly females |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |