Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ERCC3 | contributors: mct/pgu - updated : 30-08-2015 |
HGNC name | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) |
HGNC id | 3435 |
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DNA |
TYPE | functioning gene |
STRUCTURE | 36.89 kb 15 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | cytosine-phosphate-guanine/HTF |
text structure | a CpG island with several putative GC boxes in the promoter region,the first exon and the first intron |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to yeast RAD25 |
homolog to Drosophila haywire | |
homolog to murine Ercc3 (95.9pc) | |
homolog to rattus Ercc3 (95.9pc) |
intraspecies | homolog to D discoidum REPB |
Homologene |
FAMILY | |
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CATEGORY | enzyme , transcription factor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome | |
intracellular,nucleus,nucleoplasm | |
intracellular,nucleus,chromatin/chromosome |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, repair, nucleotide excision repair |
nucleotide, transcription, regulation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
nucleotide-excision repair |
a component |
INTERACTION |
DNA | binding |
RNA |
small molecule | nucleotide, |
protein | |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | XPB , TTDP2 |
Other morbid association(s) |
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Susceptibility | for TTDA (trichothiodystrophy type A) |
Variant & Polymorphism | |
Candidate gene | ||
Marker
Therapy target
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ANIMAL & CELL MODELS |