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FLASH GENE
Symbol DBI contributors: mct/ - updated : 08-11-2006
HGNC name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
HGNC id 2690
DNA
TYPE functioning gene
STRUCTURE 5.62 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site   HRE
text structure PPAR-response element (PPRE) in intron 1
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing 708 11.66 104 - 2007 17044054
4 splicing 616 9.9 87 - 2007 17044054
also called 1a
4 - 789 - 148 - -
4 - 740 - 88 highly in adipose tissue 2007 17044054
  • also called 1c
  • specific regulation of this transcript by PPARgamma2
  • might be relevant for diseases like diabetes and obesity
  • 5 - 723 14.24 129 - -
    5 - 678 11.66 104 - -
    4 - 627 11.02 97 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • an hydrophobic binding site for acylCoA esters located within the second helical region
  • an ACBP domain
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Dbi
    homolog to Drosophila tbh
    homolog to C.elegans H13N06.6
    Homologene
    FAMILY
  • ACBP family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducing medium-chain acyl-CoA ester synthesis
  • intracellular lipid-binding protein that transports acylCoA esters
  • displacing diazepan from the benzodiazepine (BZD) recognition sites located on the GABA type A receptor (acting as a neuropeptide to modulate the action of the GABA receptor)
  • downregulating the effects of GABA
  • involved in lipid metabolism and regulated by hormones and feeding status via transcription factors such as sterol regulatory element-binding protein 1 and peroxisome proliferator-activated receptor-gamma (PPARgamma)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intracellular carrier of acyl-CoA esters
    PATHWAY
    metabolism lipid/lipoprotein
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of (PPAR)gamma
  • sterol regulatory element-binding protein 1c (SREBP-1c) target gene in hepatocytes
  • cell & other
  • binding to medium and long-chain acylCoA esters
  • REGULATION
    induced by induced during adipocyte differentiation
    Other regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS