a stalk region having an essential role in ensuring functionality of the CD8alphabeta heterodimer and its replacement compromises the interaction of CD8 with peptide-MHC complexes
mediating efficient cell-cell interactions within the immune system
acting as a coreceptor
is crucial in orienting the CD8alphabeta heterodimer, providing a framework for understanding the mechanistic role of CD8alphabeta in lymphoid cell signaling
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
immunity/defense
text
anti-pathogen response
PATHWAY
metabolism
signaling
a component
heterodimer composed of one alpha and one beta chain linked by two disulfide bonds