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FLASH GENE
Symbol CD8B contributors: npt - updated : 28-03-2012
HGNC name CD8b molecule
HGNC id 1707
DNA
TYPE functioning gene
STRUCTURE 46.58 kb     7 Exon(s)
MAPPING cloned Y linked N status confirmed
Map 5'- CD8B1 - 3' - 5' - CD8A - 3'
Authors Nakayama (92)
regionally located located 35 kb upstream from the CD8 alpha locus
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1433 23.7 210 - 1992 1541829
  • also called M-1 or variant 5/isoform 5
  • type I membrane protein
  • 7 splicing 1125 - 221 - 1992 1541829
  • also called M-3 or variant 3/isoform 3
  • type I membrane protein
  • 6 splicing 1071 - 243 - 1992 1541829
  • alsos called M4 or variant 2/isoform 2
  • type I membrane protein
  • 5 splicing 981 - 213 secreted 1992 1541829
    also called S-1 or variant 4/isoform 4
    - splicing 944 - 198 - 1992 1541829
    also called variant 6/isoform 6
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like V-type domain
  • a stalk region having an essential role in ensuring functionality of the CD8alphabeta heterodimer and its replacement compromises the interaction of CD8 with peptide-MHC complexes
  • conjugated GlycoP , PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cd8b
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • mediating efficient cell-cell interactions within the immune system
  • acting as a coreceptor
  • is crucial in orienting the CD8alphabeta heterodimer, providing a framework for understanding the mechanistic role of CD8alphabeta in lymphoid cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer composed of one alpha and one beta chain linked by two disulfide bonds
  • with CD8A, forms CD8alphabeta heterodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS