Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD8A contributors: mct/npt - updated : 28-03-2012
HGNC name CD8a molecule
HGNC id 1706
DNA
TYPE functioning gene
STRUCTURE 7.11 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map pter - CD8A - IGKC IGKC - IGKJ@ - IGKV@ - cen
Authors Weichhold (93)
Physical map
MAT2A 2p11.2 methionine adenosyltransferase II, alpha GGCX 2p12 gamma-glutamyl carboxylase VAMP8 2p11.2-p11.1 vesicle-associated membrane protein 8 (endobrevin) VAMP5 2p11.2 vesicle-associated membrane protein 5 (myobrevin) LOC51255 2p11.2 hypothetical protein LOC51255 FLJ90024 2p11.2 fasting-inducible integral membrane protein TM6P1 LOC388969 2 LOC388969 USP39 2p11.2 ubiquitin specific protease 39 SFTPB 2p12-p11.2 surfactant, pulmonary-associated protein B GNLY 2p12-q11 granulysin HATH6 SIAT9 2p11.2 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) POLR1A 2p11.2 polymerase (RNA) 1 polypeptide A, 194kDa FLJ20758 2p11.2 FLJ20758 protein IMMT 2p11.2 inner membrane protein, mitochondrial (mitofilin) MRPL35 2p11.2 mitochondrial ribosomal protein L35 FLJ13110 2p11.2 hypothetical protein FLJ13110 JMJD1 2p11.2 jumonji domain containing 1 NEDF 2p24.3-p24.1 neuroendocrine differentiation factor RNF103 2p11.2 ring finger protein 103 FLJ13910 2p11.2 hypothetical protein FLJ13910 CD8A 2p12 CD8 antigen, alpha polypeptide (p32) CD8B1 2p12 CD8 antigen, beta polypeptide 1 (p37) LOC388970 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) PLGL 2p11-q11 plasminogen-like LOC388971 2 LOC388971 LOC285069 2p11.1 hypothetical protein LOC285069 LOC115281 2p11.2 similar to Ig kappa variable region MGC4677 2p11.2 hypothetical protein MGC4677 LOC388972 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) LOC388973 2 similar to plasminogen-like LOC388974 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3035 - 235 - 2007 17678538
5 - 2924 - 198 - 2007 17678538
- - 3177 - 235 - 2007 17678538
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   predominantly
 thymus   predominantly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • enhancing formation of stable T-cell receptor/MHC class I complexes
  • enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling
  • interplay between CD8A+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses
  • its expression is tightly controlled during T-cell development by the activity of five CD8 enhancers (E8(I)-E8(V)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component with CD8B, forms CD8alphabeta heterodimer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with NFIL3 (plays an essential role in the development of CD8A(+) conventional dendritic cells)
  • interacting with LNX1 or LNX2 (LNX1 or LNX2 promoted CD8A ubiquitylation, downregulation from the plasma membrane, transport to the lysosomes, and degradation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS