basic FUNCTION
| bifunctional growth-modulating glycoprotein |
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inhibiting growth of several human carcinoma cells in culture |
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stimulating proliferation of human fibroblasts and certain other tumor cells |
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important paracrine mediator of estrogen function specifically required for puberty-induced ductal elongation, but not for any earlier or later developmental stages |
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involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor |
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TGFA and EREG lead to complete receptor recycling, and AREG does not target EGFR for lysosomal degradation but causes fast as well as slow EGFR recycling |
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may play a significant role in the proliferation of osseous dysplasia |
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YAP1-dependent secretion of AREG indicates that activation of EGFR signalling is an important non-cell-autonomous effector of the Hippo pathway, which has implications for the regulation of both physiological and malignant cell proliferation |
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plays critical roles in intestinal epithelial growth |
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can increase epidermal growth factor receptor (EGFR) stability and promote EGFR localization to the plasma membrane |
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functions in regulating the invasive phenotype in cancers, and this regulation may be through altered signaling that occurs when AREG activates plasma membrane localized EGFR |
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critical for efficient Treg cell function and in addition, mast cell-derived AREG fully restored optimal Treg cell function |
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mediates progesterone-induced mammary ductal development during puberty |
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induces ovarian cancer cell invasion by down-regulating CDH1 expression |
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induces hepatic stellate cells fibrogenic activity via multiple mitogenic signaling pathways |
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participates in tissue repair and inflammation regulation |
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may be an effective new biomarker of M1 macrophages |