basic FUNCTION
| alcohol dehydrogenase (class III), chi polypeptide, zinc dependent, catalyzing the oxidation of long-chain primary alcohols and the oxidation of (hydroxymethyl) glutathione |
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alcohol dehydrogenase involved in the regulation of S-nitrosothiols (Sanghani 2009) |
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limits nitric oxide-mediated suppression of NF-kappaB and activation of soluble guanylyl cyclase (Sanghani 2009) |
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NOS3 and ADH5 play an important role in endothelial cell–mediated postnatal angiogenesis and vascular tone |
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protein key to the control of protein S-nitrosylation, is important for the development of lymphocytes |
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likely through regulation of S-nitrosylation and apoptosis, physiologically plays a protective role in the development of the immune system |
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ADH5-signaling contributes to MSC-mediated vasculogenesis |
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involvement of ADH5 and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states (for example, diabetes and cancer) |
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conserved enzyme for alcohol and aldehyde metabolism in mammals |
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negative regulator of neuronal differentiation |
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counteracts neuronal differentiation of human neural stem cells and that this effect can be reversed by pharmacological inhibition of ADH5 |