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FLASH GENE
Symbol ADH5 contributors: mct/npt - updated : 31-03-2015
HGNC name alcohol dehydrogenase 5 (class III), chi polypeptide
HGNC id 253
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
STRUCTURE 17.80 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2644 39 374 - Hur (1992)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Reproductivefemale systemuterus  highly
Respiratoryrespiratory tracttrachea  highly
Urinarykidney     Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Adh5
Homologene
FAMILY
  • alcool dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • alcohol dehydrogenase (class III), chi polypeptide, zinc dependent, catalyzing the oxidation of long-chain primary alcohols and the oxidation of (hydroxymethyl) glutathione
  • alcohol dehydrogenase involved in the regulation of S-nitrosothiols (Sanghani 2009)
  • limits nitric oxide-mediated suppression of NF-kappaB and activation of soluble guanylyl cyclase (Sanghani 2009)
  • NOS3 and ADH5 play an important role in endothelial cell–mediated postnatal angiogenesis and vascular tone
  • protein key to the control of protein S-nitrosylation, is important for the development of lymphocytes
  • likely through regulation of S-nitrosylation and apoptosis, physiologically plays a protective role in the development of the immune system
  • ADH5-signaling contributes to MSC-mediated vasculogenesis
  • involvement of ADH5 and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states (for example, diabetes and cancer)
  • conserved enzyme for alcohol and aldehyde metabolism in mammals
  • negative regulator of neuronal differentiation
  • counteracts neuronal differentiation of human neural stem cells and that this effect can be reversed by pharmacological inhibition of ADH5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    elimination of formaldehyde
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to alcohol dependence
  • to childhood asthma
  • Variant & Polymorphism other
  • increasing the risk of alcohol dependence
  • genetic polymorphisms associated to childhood asthma (Wu 2007)
  • Candidate gene
    Marker
    Therapy target target for the development of therapeutic approaches for treating lung and cardiovascular diseases (Sanghani 2009)
    ANIMAL & CELL MODELS
  • MSCs from Gsnor-deficient mice exhibited attenuated vasculogenesis
  • genetic deletion of Gsnor in mice results in significant decrease in both T and B lymphocytes in the periphery