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FLASH GENE

Symbol

ADH1A

contributors: mct/ - updated : 14-06-2006

HGNC name	alcohol dehydrogenase 1A (class I), alpha polypeptide
HGNC id	249

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	see ADH@ cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
STRUCTURE	14.62 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000667 9 - 1456 NP_000658 39.7 375 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine     highly   liver       highly   stomach pylorus     highly Endocrine adrenal gland       highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	infant liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

MetalloP

mono polymer

homomer , heteromer , dimer

HOMOLOGY

Homologene

FAMILY

zinc-containing alcohol dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	detected in the inner cell layers (Vaglenova 2003)

basic FUNCTION	alcohol dehydrogenase (class I), alpha polypeptide, zinc dependent, metabolizing a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products
	acting as retinol dehydrogenase/retinal reductase, also sites of active retinoid metabolism in the gut, essential for mucosa function and vitamin A absorption (Vaglenova 2003)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

ethanol

a component

homo- and heterodimers of alpha, beta, and gamma subunits

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

SNIP1

cell & other

REGULATION

Other

regulated by GATA2 and HNF-3beta

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased expression of ADH1A and ADH4 in non-alcoholic steatohepatitis livers (baker 2010)

Susceptibility

to alcohol dependence

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS