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FLASH GENE
Symbol CPA3 contributors: npt/ - updated : 13-02-2004
HGNC name carboxypeptidase A3 (mast cell)
HGNC id 2298
DNA
TYPE functioning gene
STRUCTURE 31.78 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1633 47 417 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic moiety with a zinc binding domain
  • conjugated MetalloP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • zinc carboxypeptidase family
  • peptidase M14 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secretory granules
    basic FUNCTION
  • cleaving COOH terminal aromatic and aliphatic aminoacid residues
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    histone hyperacety
    a component
  • binary complex with preproteinase
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    through histone deacehylase inhibitor in prostate epithelial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS