Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CNGA1 | contributors: mct - updated : 11-12-2020 |
HGNC name | cyclic nucleotide gated channel alpha 1 |
HGNC id | 2148 |
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DNA |
TYPE | functioning gene |
SPECIAL FEATURE | |
text | antisense endogenous transcript, coexpressed with Ain the brain, likely involved in synaptic plasticity and critical development |
STRUCTURE | 81.70 kb 11 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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motif | repetitive sequence ALU |
text structure | in the 5'utr |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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text | one antisense |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
Text | can be detected in growth cones |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | GlycoP |
mono polymer | heteromer , tetramer , oligo |
HOMOLOGY |
interspecies | ortholog to murine Cnga1 |
ortholog to rattus Cnga1 | |
ortholog to Canis familiari CNGC1 |
Homologene |
FAMILY |
CATEGORY | receptor membrane , transport channel |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | development , cellular trafficking transport |
text | neuronal function |
PATHWAY |
metabolism |
signaling | sensory transduction/olfaction , sensory transduction/vision |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule | metal binding, nucleotide, |
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cell & other |
REGULATION |
activated by | cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors |
Other | closed in the light |
ASSOCIATED DISORDERS |
corresponding disease(s) | RP16 |
related resource | CNGA1 Mutations |
Susceptibility |
Variant & Polymorphism
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ANIMAL & CELL MODELS |
mice lacking CNG3 display a selective loss of cone function |