basic FUNCTION
| putative upregulated c-Myc target gene |
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regulating late S and G2 phase of the cell cycle |
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regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1 |
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particularly high in these compartments, which might render stem cells dependent on cyclin A, whereas in fibroblasts cyclins A and E play redundant roles in cell proliferation |
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major regulator in vertebrate cell cycle, associated with cyclin-dependent kinase (CDK), and involved in S-phase progression and entry into mitosis |
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CCNA2 helps initiate mitosis, in part through its effects on CCNB1, and CCNB1 and CCNB2 are particularly critical for the maintenance of the mitotic state |
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role in activating CCNB/CDK1 through promoting NFYA dependent transcription of CCNB and CDC2 |
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negatively controls cell motility by promoting RHOA activation, thus demonstrating a novel CCNA2 function in cytoskeletal rearrangements and cell migration |
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key regulator of S phase progression and entry into mitosis |
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RSLISD1, PCNA, and CCNA2, which promote cell cycle progression, are repressed permanently in senescent cells |
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creates a cellular environment that promotes microtubule detachment from kinetochores in prometaphase to ensure efficient error correction and faithful chromosome segregation |
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functions as a timer in prometaphase to ensure efficient error correction, consistent with previous data showing a linear relationship between the duration of prometaphase and the level of CCNA2 |