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FLASH GENE
Symbol ANXA3 contributors: mct - updated : 06-02-2008
HGNC name annexin A3
HGNC id 541
DNA
TYPE functioning gene
STRUCTURE 57.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1634 - 323 - Park (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Hearing/Equilibriumear   highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region with four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa3
    homolog to C.elegans ZC155.1
    Homologene
    FAMILY
  • annexin family
  • calcium-dependent phospholipid-binding protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • placental anticoagulant protein III
  • playing a role in the regulation of cellular growth and in signal transduction
  • inhibiting the phosphalipase A2
  • cleaving of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (1,2-cyclic-inositol-phosphate phosphodiesterase)
  • inducing migration and tube formation of umbilical vein endothelial cells
  • angiogenic factor that induces VEGF production through the HIF-1 pathway
  • involved in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate
  • may also play a role in anti-coagulation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    inositol phosphate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS