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FLASH GENE
Symbol TBC1D21 contributors: mct - updated : 04-12-2018
HGNC name TBC1 domain family member 21
HGNC id 28536
DNA
TYPE functioning gene
STRUCTURE 38.62 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1259 - 336 - 2011 21128978
10 - 1151 - 300 - 2011 21128978
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved RABGAP catalytic domain, TBC (Tre2/Bub2/Cdc16)
  • HOMOLOGY
    Homologene
    FAMILY RABGAP family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • is likely involved in acrosome/acroplaxome formation and cytoskeletal reorganization via RAB activity during mammalian spermiogenesis
  • is a male germ cell-specific protein expressed in elongating and elongated spermatids during mammalian spermiogenesis
  • is a protein specifically expressed in the testes that exhibits specific localizations of elongating and elongated spermatids during mammalian spermiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBC1D21 is involved in mammalian spermiogenesis by modulating RAB10
  • TBC1D21 may likely interact with and potentially regulate RABGEF1 during spermatogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS