SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| localized in mitotic spindle during mitosis |
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was strictly localized in the nuclei of neurons, while it was found in the cytosolic space of astroglial and microglial processes and cell body in the adult brain |
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localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brain |
basic FUNCTION
| acting as a potential modulator of the interaction of histone 1 with chromatin |
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may mediate immune function by conferring resistance to certain opportunistic infections |
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PTMA specific localization in the heads of spermatids and epididymal spermatozoa, associated with the acrosome system, supports the hypothesis of a direct function in male germ cells |
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nuclear protein involved in cell proliferation and differentiation |
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conservation of PTMA distribution in vertebrate male gametes, strongly supporting a role for this polypeptide in their physiology |
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might play an important role in the progression of Colorectal cancer |
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nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation |
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role in the development of insulin resistance |