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FLASH GENE
Symbol TRIAP1 contributors: mct - updated : 06-07-2016
HGNC name TP53 regulated inhibitor of apoptosis 1
HGNC id 26937
DNA
TYPE functioning gene
STRUCTURE 2.45 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1196 9 76 - 2013 23931759
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a twin CX9C sequence motif that is predicted to form two disulphide bonds within the oxidising environment of mitochondrial IMS
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • is a novel apoptosis inhibitor that binds HSP70 in the cytoplasm and blocks the formation of the apoptosome and CASP9 activation
  • contributes to the maintenance of cardiolipin (CL) levels in the inner mitochondrial membrane of human cells, thereby sequestering cytochrome c and stalling apoptosis
  • modulates apoptotic pathways preventing the formation of the apoptosome complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex of TRIAP1 (p53CSV) and PRELID1 in the mitochondrial intermembrane space (IMS), which ensures the accumulation of cardiolipin in mitochondria
  • PRELID3A with its mitochondrial chaperones (TRIAP1) represent a unique heterodimeric lipid transfer system that is evolutionary conserved from yeast to man
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRIAP1 is a specific repressor of CDKN1A whose depletion slows down cell-cycle progression
  • TRIAP1/PRELID1 complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • represents a novel marker for drug resistance in breast cancer cells
  • Therapy target
    ANIMAL & CELL MODELS