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FLASH GENE
Symbol MAGOHB contributors: mct - updated : 28-04-2014
HGNC name mago-nashi homolog B (Drosophila)
HGNC id 25504
DNA
TYPE functioning gene
STRUCTURE 9.83 kb     5 Exon(s)
regulatory sequence Promoter
text structure
  • in the presence of KMT2B, neither transcription elongation nor RNA polymerase II binding is required to maintain H3K4 trimethylation at the MGOHB promoter and protect it from DNA methylation
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3034 - 148 - 2013 23358417
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • MAGOH and MAGOHB contribute to exon junction complex composition and nonsense-mediated decay
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of STAU2 with the Y14-MAGOHB heterodimer seems to represent a highly conserved complex as the same proteins are involved in the STAU2-mediated localization of Oskar mRNA in Drosophila oocytes
  • in the presence of KMT2B, neither transcription elongation nor RNA polymerase II binding is required to maintain H3K4 trimethylation at the MAGOHB promoter and protect it from DNA methylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS