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FLASH GENE
Symbol SIMC1 contributors: mct - updated : 11-04-2014
HGNC name SUMO-interacting motifs containing 1
HGNC id 24779
DNA
TYPE functioning gene
STRUCTURE 107.62 kb     12 Exon(s)
text structure composed of 12 exons, of which exon 3 encodes the canonical first Met
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2087 - 457 - 2013 23707407
10 - - - - predominant variant in skeletal muscle, not identified in other human tissues, such as brain or testis 2013 23707407
lacks exons 2 and 3
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
Reproductivemale systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region interacts with CTBP1
  • C-terminal sequence, which harbors the CAPN3 inhibitory or regulatory activity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text primarily distributed diffusely in the cytoplasm
    basic FUNCTION
  • can shift its major function from CAPN3 suppression to CAPN3-substrate recruitment, depending on the cellular context
  • novel suppressor and scaffold for CAPN3, scaffolds CAPN3 to direct and regulate its substrate-proteolyzing activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a CAPN3-binding protein and suppresses the protease activity of CAPN3
  • also interacts with CTBP1 (C-terminal binding protein 1), a transcriptional co-regulator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS