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FLASH GENE
Symbol PIK3R6 contributors: mct - updated : 10-02-2014
HGNC name phosphoinositide-3-kinase, regulatory subunit 6
HGNC id 27101
DNA
TYPE functioning gene
STRUCTURE 64.94 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text 1
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3061 84 754 - 2005 15797027
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to PIK3R5
Homologene
FAMILY
CATEGORY adaptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • differential functions of the two PIK3CG regulatory subunits PIK3R5, and PIK3R6 in the process of oncogenesis
  • non-catalytic subunit assumed to be redundant adaptors for GNB1/GNGT1 enabling G-protein-coupled receptor-mediated regulation of PIK3CG
  • specific regulatory roles of PIK3R5, PIK3R6 in the differentiation of PIK3CG a signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PIK3CG has two potential regulatory subunits PIK3R5, PIK3R6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of PIK3R6 to PIK3CG substantially increases the ability of Gbetagamma to stimulate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) production
  • like PIK3R5, PIK3R6 binds to both PIK3CG and Gbetagamma and mediates activation of PIK3CG downstream of G protein-coupled receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS