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FLASH GENE

Symbol

CD300LD

contributors: mct - updated : 12 -11-201

HGNC name	CD300 molecule-like family member d
HGNC id	16848

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	six members (CD300A–CD300F) are clustered in a 450-kb region of human chromosome 17
STRUCTURE	12.26 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001115152 4 - 644 NP_001108624 21.5 194 - 2012 2229100

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Homo sapiens Blood/Hematopoietic monocyte Homo sapiens

cell lineage	expressed in cells of myeloid lineage
cell lines
fluid/secretion

at STAGE

physiological period

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	type I transmembrane receptor driven by a signal peptide 18 AA in length
	a single extracellular Ig V-type domain
	function of CD300d would be related to the regulation of the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface

HOMOLOGY

intraspecies

homolog to CD300LF

Homologene

FAMILY

CD300 family of immune receptors

CATEGORY

immunity/defense , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	retained intracellularly and more specifically within the ER

basic FUNCTION	function of CD300LD would be related to the regulation of the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface
	could play a role in the regulation and/or formation of CD300 complexes on the cell surface and consequently modulate the state of activation of myeloid cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forms complexes with the CD300 family members, with the exception of CD300C
	was able to form homocomplexes

INTERACTION

DNA

RNA

small molecule

protein	CD300LD recruited FCER1G as efficiently as CD300C
	able to recruit the adaptor DAP12 as efficiently as CD300C
	is able to recruit the ITAM-bearing adaptor FCER1G, suggesting that if this receptor is able to reach the cell surface, it could deliver activating signals after engagement with a specific ligand similarly to CD300C
	interacts with all members of the CD300 family with the exception of CD300C

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS